Table 3. Validity of verbal autopsy based assignment of any cause* of neonatal deaths compared with the cause of death assigned by the treating neonatologist based on clinical and laboratory information.
Diagnosis Category | Sensitivity | Specificity | Positive Predictive Value | Negative Predictive Value | Diagnostic Accuracy | Area under ROC | Kappa Agreement | ||
N | % | N | % | % | % | % | Proportion | Agreement | |
(95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | |||
Congenital Anomaly | 36 | 61.1 | 277 | 95.7 | 68.8 | 95.0 | 92.3 | 0.78 | 0.58 |
(43.5–76.4) | (92.4–97.6) | (49.9–83.3) | (91.6–97.1) | (88.8–95.0) | (0.71–0.87) | (0.44–0.73) | |||
Preterm birth | 87 | 81.6 | 226 | 69.0 | 50.4 | 90.7 | 72.5 | 0.75 | 0.43 |
(71.6–88.8) | (62.5–74.9) | (41.9–58.8) | (85.1–94.4) | (67.2–77.4) | (0.70–0.80) | (0.33–0.57) | |||
Asphyxia | 85 | 54.1 | 228 | 89.0 | 64.8 | 83.9 | 79.6 | 0.72 | 0.45 |
(43.0–64.9) | (84.1–92.6) | (52.5–75.5) | (78.5–88.2) | (74.6–83.9) | (0.66–0.77) | (0.34–0.57) | |||
Severe infection (pneumonia, sepsis or meningitis) | 91 | 78.0 | 222 | 66.2 | 48.6 | 88.0 | 69.6 | 0.72 | 0.37 |
(67.9–85.8) | (59.5–72.3) | (40.3–57.0) | (81.9–92.4) | (64.2–74-7) | (0.67–0.77) | (0.28–0.47) |