. 2013 Jan 25;8(1):e54877. doi: 10.1371/journal.pone.0054877

Table 3. Interactions of MG(1,4,5)IP₃ with type 1 IP₃ receptors.

	DT40-IP₃R1 cells			Cerebellum
	EC₅₀ (nM)	pEC₅₀ (/M)	Maximal Ca²⁺ release (%)	K_D (nM)	pK_D (/M)	pK_D-pEC₅₀
(1,4,5)IP₃	91	7.04±0.1	77±2	5.13	8.29±0.03	1.25±0.29
MG(1,4,5)IP₃	447	6.35±0.12	73±4	37.2	7.43±0.08	1.08±0.35

Results from functional assays of Ca²⁺ release from DT40-IP₃R1 cells (Figure 7B) and of equilibrium competition binding to cerebellar membranes (Figure 7C) compare the pEC₅₀ and pK_D values for (1,4,5)IP₃ and MG(1,4,5)IP₃. Results (except EC₅₀ and K_D) show means ± SEM from 3–9 independent experiments. The final column shows pK_D-pEC₅₀ for each ligand.

Table 3. Interactions of MG(1,4,5)IP3 with type 1 IP3 receptors.

Table 3. Interactions of MG(1,4,5)IP₃ with type 1 IP₃ receptors.