Table 2. Distribution of activated HER kinase axis members in GCs.
| CEER MARKER | HISTOTYPE | HER2(+) (n = 50) | HER2(−) (n = 384) | Sample % based on histotype |
| pHER1 | Intestinal (n = 154) | 7 | 31 | 24.7% |
| Diffuse (n = 225) | 4 | 54 | 25.8% | |
| Mixed (n = 18) | 2 | 1 | 16.7% | |
| ND (n = 37) | 0 | 10 | 27.0% | |
| % based on HER2 status | 26.0% | 25.0% | ||
| pHER2 | Intestinal (n = 154) | 22 | 33 | 35.7% |
| Diffuse (n = 225) | 2 | 41 | 19.1% | |
| Mixed (n = 18) | 1 | 5 | 33.3% | |
| ND (n = 37) | 0 | 5 | 13.5% | |
| % based on HER2 status | 50.0% | 21.9% | ||
| pHER3 | Intestinal (n = 154) | 13 | 33 | 29.9% |
| Diffuse (n = 225) | 3 | 46 | 21.8% | |
| Mixed (n = 18) | 2 | 3 | 27.8% | |
| ND (n = 37) | 0 | 9 | 24.3% | |
| % based on HER2 status | 36.0% | 23.7% | ||
| pHER1+pHER2 | Intestinal (n = 154) | 6 | 23 | 18.8% |
| Diffuse (n = 225) | 1 | 27 | 12.4% | |
| Mixed (n = 18) | 1 | 1 | 11.1% | |
| ND (n = 37) | 0 | 5 | 13.5% | |
| % based on HER2 status | 16.0% | 14.6% | ||
| pHER1+pHER3 | Intestinal (n = 154) | 2 | 19 | 13.6% |
| Diffuse (n = 225) | 1 | 31 | 14.2% | |
| Mixed (n = 18) | 2 | 1 | 16.7% | |
| ND (n = 37) | 0 | 6 | 16.2% | |
| % based on HER2 status | 10.0% | 14.8% | ||
| pHER2+pHER3 | Intestinal (n = 154) | 11 | 22 | 21.4% |
| Diffuse (n = 225) | 1 | 28 | 12.9% | |
| Mixed (n = 18) | 1 | 3 | 22.2% | |
| ND (n = 37) | 0 | 4 | 10.8% | |
| % based on HER2 status | 26.0% | 14.8% | ||
| pHER1+pHER2+pHER3 | Intestinal (n = 154) | 2 | 17 | 12.3% |
| Diffuse (n = 225) | 1 | 22 | 10.2% | |
| Mixed (n = 18) | 1 | 1 | 11.1% | |
| ND (n = 37) | 0 | 4 | 10.8% | |
| % based on HER2 status | 8.0% | 11.5% |
Distribution of samples with respect to each activated HER kinase axis receptor member and its coactivation with other HER members. HER2 status and histological subtype of the samples is indicated. ND: not defined.