Table 2.
The weight of vital organs in rats treated orally with the Methanolic extract of the bark of Aegle marmelos (L.) 200 mg, 400 mg and 600 mg per kg body weight (bw) per day (values are mean ± SEM, n = six animals)
|
Treatment schedule |
Brain |
Thyroid |
Heart |
Lungs |
Liver |
Spleen |
Adrenal |
Kidney |
|
|---|---|---|---|---|---|---|---|---|---|
| (g) | (g) | (g) | (g) | (g) | (g) | (g) | (g) | ||
| C |
|
1.828 ± 0.220 |
0.020 ±0.004 |
0.716 ±0.024 |
1.497 ±0.292 |
8.167 ±0.818 |
0.601 ±0.200 |
0.176 ± 0.002 |
1.742 ±0.240 |
| SD |
20 D |
1.833 ± 0.243 |
0.020 ±0.004 |
0.714 ±0.024 |
1.502 ±0.301 |
8.0 ±0.801 |
0.614 ±0.210 |
0.177 ±0.002 |
1.765 ±0.261 |
| |
40 D |
1.845 ± 0.254 |
0.020 ±0.004 |
0.741 ±0.028 |
1.487 ±0.281 |
7.967 ±0.793 |
0.625 ±0.220 |
0.175 ±0.002 |
1.752 ±0.251 |
| |
60 D |
1.845 ± 0.250 |
0.020 ±0.004 |
0.726 ±0.027 |
1.508 ±0.301 |
7.967 ±0.791 |
0.615 ±0.211 |
0.178 ±0.002 |
1.755 ±0.252 |
| G I |
20 D |
1.773 ± 0.194 |
0.019 ±0.003 |
0.681 ±0.194 |
1.457 ±0.251 |
8.307 ±0.830 |
0.611 ±0.210 |
0.176 ±0.002 |
1.743 ±0.241 |
| |
40 D |
1.882 ± 0.276 |
0.019 ±0.003 |
0.724 ±0.027 |
1.519 ±0.312 |
8.213 ±0.820 |
0.593 ±0.197 |
0.173 ±0.002 |
1.728 ±0.227 |
| |
60 D |
1.803 ± 0.204 |
0.020 ±0.004 |
0.720 ±0.026 |
1.498 ±0.300 |
7.945 ±0.790 |
0.616 ±0.211 |
0.178 ±0.002 |
1.720 ±0.220 |
| G II |
20 D |
1.738 ± 0.187 |
0.020 ±0.004 |
0.723 ±0.026 |
1.517 ±0.311 |
8.249 ±0.820 |
0.592 ±0.196 |
0.177 ± 0.002 |
1.732 ±0.231 |
| |
40 D |
1.858 ± 0.256 |
0.020 ±0.003 |
0.761 ±0.029 |
1.542 ±0.331 |
7.95 ±0.800 |
0.615 ±0.211 |
0.171 ±0.002 |
1.782 ±0.281 |
| |
60 D |
1.82 ± 0.225 |
0.020 ±0.004 |
0.735 ±0.028 |
1.478 ±0.271 |
8.25 ±0.822 |
0.591 ±0.196 |
0.169 ±0.001 |
1.707 ±0.279 |
| G III |
20 D |
1.842 ± 0.254 |
0.020 ±0.004 |
0.718 ±0.024 |
1.485 ±0.282 |
8.417 ±0.842 |
0.646 ±0.222 |
0.181 ±0.003 |
1.805 ±0.306 |
| |
40 D |
1.728 ± 0.179 |
0.019 ±0.003 |
0.716 ±0.025 |
1.503 ±0.301 |
7.783 ±0.748 |
0.651 ±0.230 |
0.177 ±0.002 |
1.70 ±0.201 |
| |
60 D |
1.898 ± 0.284 |
0.021 ±0.005 |
0.85 ±0.032 |
1.517 ±0.311 |
7.9 ±0.798 |
0.617 ±0.213 |
0.175 ±0.002 |
1.807 ±0.309 |
| R G I |
30 D |
1.833 ± 0.243 |
0.020 ±0.003 |
0.733 ±0.027 |
1.518 ±0.313 |
8.1 ±0.810 |
0.594 ±0.198 |
0.179 ±0.002 |
1.79 ±0.280 |
| R G II |
30 D |
1.828 ± 0.224 |
0.020 ±0.004 |
0.716 ±0.024 |
1.497 ±0.300 |
8.167 ±0.818 |
0.600 ±0.200 |
0.176 ±0.002 |
1.742 ±0.241 |
| R G III | 30 D | 1.865 ± 0.255 | 0.020 ±0.003 | 0.810 ±0.031 | 1.493 ±0.300 | 8.051 ±0.806 | 0.594 ±0.194 | 0.175 ±0.002 | 1.803 ±0.307 |
Significance level: a P ≤ 0.01 compared Control.
C- Rats treated with treated with in 2.0 ml 0.5 percent CMC each day for 60 days.
SD- Rats treated with standard drug 50 mg/rat/day/p.o lonidamine.
G I- Rats treated with methanolic bark extract of Aegle marmelos 200 mg/rat/day/p.o.
GII- Rats treated with methanolic bark extract of Aegle marmelos 400 mg/rat/day/p.o.
GIII- Rats treated with methanolic bark extract of Aegle marmelos 600 mg/rat/day/p.o.
RG-I- Rats withdraw from treated for 30 days after 60 days treatment of methanolic bark extract of Aegle marmelos 200 mg/rat/day/p.o.
RG-II- Rats withdraw from treated for 30 days after 60 days treatment of methanolic bark extract of Aegle marmelos 400 mg/rat/day/p.o.
RG-III- Rats withdraw from treated for 30 days after 60 days treatment of methanolic bark extract of Aegle marmelos 600 mg/rat/day/p.o.