Table 2.
Effects of Imipramine and Fluoxetine on serum TC and TG levels, and BW
| Groups | Paired t-test; Within groups changes between weeks 0 and 4 (p value) | Paired t-test; Within groups changes between weeks 4 and 8 (p value) | Repeated measures ANOVA; F (p value) |
|---|---|---|---|
|
TC level (mg/dL) |
|
|
|
| Imipramine |
|
|
|
| √ All subjects |
9.59 (0.07**) |
30.00 (<0.001*) |
24.68 (<0.001*) |
|
o Male |
11.54 (0.21) |
22.92 (<0.001*) |
11.07 (<0.001*) |
|
o Female |
8.00 (0.22) |
35.75 (0.003*) |
13.88 (<0.001*) |
| Fluoxetine |
|
|
|
| √ All subjects |
9.00 (0.07**) |
12.77 (0.16) |
2.93 (0.07**) |
|
o Male |
6.80 (0.39) |
19.10 (0.006*) |
6.67 (0.027*) |
|
o Female |
12.14 (0.04*) |
3.72 (0.86) |
0.22 (0.810) |
|
TG level (mg/dL) |
|
|
|
| Imipramine |
|
|
|
| √ All subjects |
17.10 (0.005*) |
32.07 (<0.001*) |
18.88 (<0.001*) |
|
o Male |
11.75 (0.013*) |
26.75 (<0.001*) |
24.06 (<0.001*) |
|
o Female |
20.66 (0.036*) |
35.62 (0.007*) |
9.53 (0.001*) |
| Fluoxetine |
|
|
|
| √ All subjects |
13.47 (<0.001*) |
5.47 (0.56) |
2.59 (0.09) |
|
o Male |
14.27 (0.016*) |
9.36 (0.30) |
3.24 (0.06**) |
|
o Female |
12.00 (<0.001*) |
1.67 (0.94) |
0.26 (0.78) |
|
BW (Kg) |
|
|
|
| Imipramine |
|
|
|
| √ All subjects |
1.42 (<0.001*) |
1.18 (<0.001*) |
29.70 (<0.001*) |
|
o Male |
1.07 (0.009*) |
1.00 (0.007*) |
11.56 (<0.001*) |
|
o Female |
1.66 (<0.001*) |
1.31 (0.008*) |
18.54 (0.001*) |
| Fluoxetine |
|
|
|
| √ All subjects |
0.02 (0.88) |
0.45 (0.20) |
1.51 (0.24) |
|
o Male |
0.18 (0.44) |
0.05 (0.85) |
0.41 (0.54) |
| o Female | 0.36 (0.25) | 1.21 (0.14) | 4.06 (0.05**) |
* Statistically significant effect ** Trend towards significant effect.