Table 1.

Gene set enrichment analysis (GSEA)

Group	Gene set	Size	ES	NES	p value	FDR
Enriched in CDH
1	nucleosome	14	0.76	2.34	0.00	0.84
2	structural constituent of eye lens	12	0.72	2.16	0.00	6.16
3	inner ear morphogenesis	21	0.61	2.15	0.00	4.38
4	nucleosome assembly	21	0.59	2.03	0.00	11.71
5	chromatin assembly	21	0.59	2.03	0.00	9.36
6	intramolecular oxidoreductase activity	16	0.61	1.96	0.01	14.74
7	DNA-dependent DNA replication	19	0.53	1.85	0.00	31.63
8	DNA packaging	24	0.50	1.82	0.00	33.31
9	methylation	43	0.41	1.78	0.00	40.09
10	methyltransferase activity	43	0.41	1.78	0.00	36.08
Enriched in MDH
1	proteasomal ubiquitin-dependent protein catabolic process	60	−0.51	−2.01	0.00	12.63
2	proteasomal protein catabolic process	60	−0.51	−2.01	0.00	6.32
3	ubiquitin-protein ligase activity	71	−0.49	−1.93	0.00	14.41
4	protein ubiquitination	94	−0.46	−1.92	0.00	13.14
5	regulation of protein catabolic process	10	−0.75	−1.92	0.00	10.60
6	protein modification by small protein conjugation	101	−0.45	−1.90	0.00	11.47
7	ubiquitin thiolesterase activity	33	−0.54	−1.88	0.00	13.19
8	thiolester hydrolase activity	42	−0.51	−1.87	0.00	12.49
9	protein modification by small protein conjugation or removal	123	−0.43	−1.87	0.00	11.58
10	membrane raft	65	−0.47	−1.86	0.00	11.47
11	cellular protein catabolic process	129	−0.42	−1.86	0.00	10.68
12	proteolysis involved in cellular protein catabolic process	129	−0.42	−1.86	0.00	9.79

Direct comparison of genes uniquely expressed in cod larvae in the CDH and MDH exposure groups. Size: number of genes in each gene set. ES = enrichment score. NES = normalized enrichment score. Nominal p value. FDR = false discovery rate.