Skip to main content
. 2013 Jan 25;8(1):e54630. doi: 10.1371/journal.pone.0054630

Figure 6. WNT U-shaped binding pocket with two hydrophobic arms grasping Frizzled CRD.

Figure 6

N-terminal binding Site 1 contains most hydrophobic amino acid residues including Leu-3, Ala-5, and Pro-8. Binding site 2 is present at C-terminal end. This binding site was found to be most conserved in all WNT proteins, ranging between amino acid residues 300–325. The opening of the U-groove is 28 Å wide. The groove then widens to 31 Å, before narrowing to 17 Å at its centre and finally widening again to 27 Å at the base.