Table 2. Cellular Functions of Identified Proteins.
| Functions | Identified Proteins |
| Cell Signaling | ALOX15, NRAS, RAB3A, CFL1, RRAD, ATP2A1, RAB7A, ATP2A3, LOC643751, NOS3, RAP1A, KPNB1, TGM2, GNB1, PPP2CB, HP, RRAS2, CADPS, GNAO1, EEF1A1, DNAJA3, YWHAQ (includes EG:22630), IPO5, NME2, RHEB, (STAT4, GNAI2, GNAS, RHOG, PRKAA1, LOC643751, YWHAE, STAT1), (HK1, MTOR, ERP44, GRB2, RSU1, PPP3CA, SOD1, SOD2) |
| Cell-To-Cell Signaling and Interaction | EHD1, ALOX15, CFL1, RAB21, APOA1, RRAD, CD36, INPPL1, NOS3, RAP1A, GNB1, ROCK2, TGM2, PLA2G6, CAPN1, TXN, MARCKS (includes EG:4082), CLIC4, AKR1B1, HSPB1, FGA, (GNAI2, STAT4, GNAS, PSME1, SERPINC1, C3, MAP2K3, STAT3, LOC643751, STAT1, Ube2n, YWHAG, TNS1), (SLK, MTOR, GRB2, RSU1, SOD1, SOD2) |
| Energy Production | DLD, CD36, PRKAA2, NOS3, LONP1, MSRA PRDX5 UBA1, (ECHS1, ECI1) |
| Nucleic AcidMetabolism | NRAS, ACACB, CD36, RAB7A, NOS3, TGM2, KPNB1, GNB1, RRAS2, GNAO1, EEF1A1, DLD, PRKAA2, MLYCD, HMGCL, ALDH2, NME2, AKR1B1, ALDH6A1, PRDX5, UBA1, LONP1, IPO5, (GNAI2, GNAS, AMPD3, GPD1, STAT3), (ADSL, GFPT1, SOD1) |
| Lipid Metabolism | QKI, APOA1, PTPMT1, CRAT, SH3GLB1, LIPE, INPPL1, NOS3, ROCK2, GNB3, PTGES2, HBB (includes EG:3043), GPLD1, PRKAA2, MGLL, MARCKS (includes EG:4082), GPX4, HMGCL, PITPNB, PLA2G16, ALOX15, ACACB, RAB5A, RRAD, RAB7A, CD36, PCYT1A, PLA2G6, HP, ARF1, GNAO1, CPT2, DLD, EEF1A1, AKR1B1, MAP4, TPP1, MLYCD, (GNAI2, GNAS, SERPINC1, SDHB, LPIN1, C3, FABP4, PCCA, YWHAH, ECHS1, ECI1, SUCLG1, PRKAA1), (SDHA, MTOR, ACBD3, SOD1, SOD2) |
| Carbohydrate Metabolism | IDH3G, APOA1, PTPMT1, PPP1CB, LIPE, CRAT, SH3GLB1, FN3K, INPPL1, NOS3, PRKAG1, GNB1, ROCK2, HK2, GPLD1, PRKAA2, MGLL, PPM1A, IDH3A, GPX4, MARCKS (includes EG:4082), PLA2G16, ACACB, AKR1B1, ALDH2, SLC9A3R1, RAB5A, RRAD, COQ3, CD36, PFKM, PCYT1A, PLA2G6, ARF1, EEF1A1, MLYCD, (C3, GPD1, PRKAA1, STAT3, PGAM2, ACO1, FABP4), (HK1, MTOR, GFPT1, GRB2, SOD1, SOD2) |
| Amino AcidMetabolism | PPP2CB, PPP2R1A, PPP2CA, PPP1CB, PPM1A, NOS3, ALDH6A1, MSRA, PCYT1A, (MTHFD1,PCCA), (SLK, HK1, MTOR, PPP2R2A, F2, PPP3CA, SOD1) |
| Small Molecule Biochemistry | QKI, PPP2CA, SH3GLB1, LIPE, NOS3, GNB1, ROCK2, GNB3, PTGES2, HBB (includes EG:3043), CADPS, MGLL, PPM1A, GPX4, PITPNB, ACACB, RRAD, PFKM, PPP2CB, PLA2G6, PPP2R1A, GNAO1, DLD, CPT2, MLYCD, APOA1, IDH3G, PTPMT1, PPP1CB, CRAT, FN3K, INPPL1, PRKAG1, TGM2, HK2, GPLD1, PRKAA2, IDH3A, MARCKS (includes EG:4082), HMGCL, LONP1, IPO5, PLA2G16, ALOX15, NRAS, RAB5A, COQ3, CD36, RAB7A, PCYT1A, KPNB1, ARF1, HP, ALDH2, ALDH6A1, AKR1B1, PRDX5, MSRA, NME2, MPST, MAP4, UBA1, RRAS2, EEF1A1, TPP1, (AMPD3, SDHB, GPD1, C3, YWHAZ, STAT3, MTHFD1, GNAI2, STAT4, GNAS, GPX3, SERPINC1, LPIN1, PRKAA1, AKR7A2, PCCA, APRT, SUCLG1, FABP4, YWHAH, ACO1, ECHS1, ECI1, PGAM2, STAT1), (SLK, SDHA, HK1, ADSL, MTOR, GFPT1, ERP44, PPP2R2A, GRB2, ACBD3, PPP3CA, SOD1, SOD2) |
| Molecular Transport | RAB1A, APOA1, RAB2A, ATP2A1, CRAT, LIPE, PPP1CB, INPPL1, NOS3, ROCK2, HK2, HBB (includes EG:3043), COQ7, CADPS, PRKAA2, PPM1A, MGLL, PITPNB, ALOX15, NRAS, ACACB, RAB3A, RAB5A, CFL1, TIMM44, RRAD, RAB10, RAB7A, CD36, ATP2A3, PCYT1A, KPNB1, PLA2G6, HP, ARF1, ARF3, GNAO1, CPT2, EEF1A1, DLD, RAB3GAP2, MLYCD, PRDX5, AKR1B1 ALDH2, NME2, CLIC4, RAB6A, (GNAI2, GNAS, SERPINC1, LPIN1, C3, YWHAZ, ACO1, YWHAE, FABP4, APRT, NDRG2, YWHAH, PGAM2, ECI1, STAT3), (GFPT1, MTOR, ERP44, GRB2, ACBD3, PPP3CA, SOD1, SOD2) |
| Protein Trafficking | RAB1A, RAB5A, TIMM44, CFL1, RAB2A, CD36, RAB10, RAB7A, KPNB1, ARF1, ARF3, RAB3GAP2, NME2, RAB6A, (YWHAE, YWHAG), (MTOR, SOD1, SOD2) |
| DNA Replication/Recombination/Repair | NRAS, CFL1, RAB7A, TGM2, KPNB1, GNB1, DYNLL1, RRAS2, GNAO1, PRKAA2, TXN, HSPB1, NME2, SELENBP1, UBA1, LONP1, IPO5, (GNAI2, GNAS, AMPD3, GPD1, PIN1, STAT1), (SOD1, SOD2) |
| Gene Expression | PTGES2, PPP2CA, (STAT4, GNAS, SERPINC1, YWHAZ, MAP2K3, STAT3, PIN1, STAT1, ELAVL1, YWHAE, ACO1, TCEB1), (GFPT1, MTOR, PSMC3) |
| Cellular Function and Maintenance | EHD1, NRAS, RAB5A, RAB3A, ATP2A1, CD36, RAB7A, LIPE, NOS3, TGM2, ROCK2, DYNC1H1, PLA2G6, FIS1, HP, DYNLL1, EHD4, CADPS, EHD2, PRKAA2, TXN, DNM1L, (GNAI2, STAT4, GNAS, SERPINC1, LPIN1, C3, SEC23IP, PRKAA1, STAT3, STAT1, LOC643751), (HK1, MTOR, PLS3, GRB2, RSU1, PPP3CA) |
| Cellular Compromise | EHD1, ALOX15, RAB1A, CFL1, RRAD, ATP2A1, NOS3, ROCK2, FIS1, DYNLL1, HP, DSTN, DLD, ALDH2, CLIC4, AKR1B1, TXN, DNM1L, (C3, OPA1, SORBS2, STAT3), (SLK, SDHA, MTOR, COX4I1) |
| Cell Cycle | ARL8B, CUL5, PPP2CA, CUL4A, CUL1, DDX3X, LIPE, LOC643751, ROCK2, DSTN, PPM1A, TXN, MARCKS (includes EG:4082), PLA2G16, ALOX15, ACACB, NRAS, CFL1, RRAD, DDB1, FIS1, PPP2CB, SIRT2, AKR1B1, MAP4, CAPN2, DNM1L, (GNAI2, STAT4, GNAS, C3, OPA1, MAP2K3, PIN1, STAT3, STAT1, LOC643751, YWHAE, NPEPPS, ELAVL1), (MTOR, PPP2R2A, GRB2, PPP3CA, SOD1, SOD2) |
| Cellular Assembly and Organization | RAB1A, RAB12, RAB2A, APOA1, ATP2A1, SH3GLB1, LIPE, INPPL1, RAB5B, LOC643751, NOS3, ROCK2, GNB1, DYNLL1, HK2, CADPS, RAB5C, EHD2, DSTN, ARL1, DNAJA3, SLC9A3R2, TXN, MARCKS (includes EG:4082), EHD1, RAB3A, CFL1, MAP4, HSPB1, SELENBP1, CLIC4, RAB5A, RAB7A, PCYT1A, FIS1, ARF1, CAPNS1, ARF3, CAPN1, SAR1A, GNAO1, EEF1A1, TPP1, DNM1L, RAB6A, (LRBA, C3, SEC23IP, YWHAZ, BASP1, STAT3, LOC643751, IQGAP1, GNAI2, GNAS, SERPINC1, NOL3, LPIN1, RHOG, OPA1, SORBS2, PIN1, NFS1, YWHAG, TNS1), (HK1, MTOR, PLS3, GRB2, PPP3CA, SOD1, SOD2) |
| Cell Morphology | EHD1, NRAS, RAB1A, CFL1, RRAD, ATP2A1, SH3GLB1, LIPE, NOS3, LOC643751, ROCK2, FIS1, HK2, FLNC, MARCKS (includes EG:4082), GPX4, CLIC4, HSPB1, MAP4, DNM1L, (SEC23IP, YWHAZ, BASP1, STAT3, LOC643751, IQGAP1, STAT4, GNAS, SERPINC1, LPIN1, NOL3, RHOG, PRKAA1, OPA1, SORBS2, MAP2K3, PIN1, NFS1,YWHAE, YWHAG, CRIP2, TNS1), (HK1, MTOR, GRB2, SOD1, SOD2) |
| Cellular Movement | CUL5, APOA1, MYLK3, LIPE, DDX3X, NOS3, LOC643751, HNRNPK, ROCK2, TGM2, DNAJA3, FGB, MGLL, SLC9A3R2, TXN, MARCKS (includes EG:4082), EHD1, NRAS, RAB21, SLC9A3R1, CFL1, CD36, RAP1A, PLA2G6, HP, CAPNS1, RRAS2, CAPN1, GNAO1, CAPN2, AKR1B1, CLIC4, HSPB1, NDRG2, NME2,FGA, (GNAI2, GNAS, SERPINC1, C3, RHOG, MAP2K3, PIN1, STAT3, IQGAP1, LOC643751, STAT1, TNS1) |
| Cell Death/Survival | CUL5, QKI, APOA1, PPP2CA, CUL4A, CUL1, ATP2A1, BAG3, SH3GLB1, LIPE, DDX3X, INPPL1, NOS3, LOC643751, ROCK2, CIAPIN1, GNB1, TGM2, DYNLL1, HK2, PRKAA2, DNAJA3, SLC9A3R2, PPM1A, TXN, GPX4, RHEB, PLA2G16, ALOX15, NRAS, CD36, SIRT3, PFKM, PPP2CB, PLA2G6, FIS1, PPP2R1A, TUBA1A, CAPNS1, RRAS2, SIRT2, CAPN1, GNAO1, EEF1A1, TPP1, CLIC4, MAP4, UBA1 HSPB1, AKR1B1, ALDH2, MAP4, NME2, PRDX5, SELENBP1, UBA1, MSRAD, NM1L, (SDHB, C3, YWHAZ, STAT3, LOC643751, ELAVL1, STAT4, GNAS, SERPINC1, NOL3, PRKAA1, OPA1, MAP2K3, SORBS2, PIN1, STAT1), (SDHA, SLK, HK1, MTOR, GFPT1, PPP2R2A, GRB2, BAT3, PPP3CA, SOD1, SOD2) |
| Cellular Development | EHD1, ALOX15, NRAS, RRAD, LIPE, NOS3, LOC643751, ROCK2, FIS1, PLA2G6, PPP2R1A, SIRT2, FLNC, PPM1A, MARCKS (includes EG:4082), ALDH6A1, CLIC4, NME2, SELENBP1, NDRG2, UBA1, AKR1B1, FGA, (STAT4, GNAS, LPIN1, C3, BASP1, MAP2K3, PIN1, STAT3, STAT1, LOC643751, FABP4, Ube2n, FABP4, YWHAG, ELAVL1), (MTOR, GRB2, SOD1, SOD2) |
| Cellular Growth and Proliferation | RAB1A, PRKAB1, PPP2CA, APOA1, CUL1, DDX3X, NOS3, LOC643751, HNRNPK, ROCK2, ARL1, DNAJA3, PPM1A, SLC9A3R2, TXN, GPX4, ALOX15, NRAS, SLC9A3R1, RRAD, PSME2, DDB1, DYNC1H1, PLA2G6, ARF1, PPP2R1A, PSMC1, CAPNS1, SIRT2, CAPN1, PSMD2, NME2, NDRG2, AKR1B1, UBA1, GNAO1, (STAT4, SERPINC1, RHOG, LPIN1, C3, PRKAA1, MAP2K3, STAT3, PIN1, STAT1, LOC643751, ELAVL1), (HK1, MTOR, GRB2, PSMC3, PPP3CA, SOD1, SOD2) |
| Post-Translational Modification | CUL5, APOA1, PPP2CA, CUL1, CD36, PPP1CB, SH3GLB1, SIRT3, TTC1, NOS3, DDB1, PPP2CB, PPP2R1A, UGGT1, SIRT2, CAPN1, DNAJA3, CAPN2, PPM1A, ALDH2, MSRA, TXN, (CAND1, FAM129A, UBE2D2, YWHAZ, STAT1, TCEB1), (SLK, ADSL, HK1, GFPT1, MTOR, ERP44, PPP2R2A, PPP3CA, SOD1, SOD2) |
| Protein Folding | UGGT1, DNAJA3, SH3GLB1, TXN, TTC1 |
| Protein Synthesis | ALOX15, PRKAB1, PRKAG1, PFKM, TGM2, HBB (includes EG:3043), CAPNS1, CAPN1, PRKAA2, DLD, TPP1, CAPN2, HSPB1, CLIC4, NME2, LONP1, (KIAA0368, UBE2D2, MAP2K3, UBE2D3 (includes EG:66105)), (ADSL, GFPT1, MTOR, ERP44, GRB2, PSMC4, PSMC2, SOD1, SOD2) |
| Protein Degradation | ALOX15, CAPNS1, CAPN1, DLD, TPP1, CAPN2, LONP1, (KIAA0368, UBE2D2, UBE2D3 (includes EG:66105)), (MTOR, PSMC4, PSMC2, SOD1, SOD2) |
Normal: proteins identified both in BI-occupied and Cz-occupied β2ARr•HDL pull-downs.
(Italic): proteins identified in BI-occupied β2ARr•HDL pull-downs. (Bold): proteins identified in Cz-occupied β2AR•rHDL pull-downs.