Table 11.
Paw edema data obtained on carrageenan induced rats half an hour after the patch application (data represented as mean ± S.D, n = 4)
|
Time (h) | ||||||||||||||
| |
0.5 |
0.75 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
10 |
12 |
16 |
24 |
|
% Edema with respect to initial volume | ||||||||||||||
|
Control |
3.57 ±1.08 |
14.28 ± 2.05 |
35.71 ± 7.06 |
42.8 ±9.64 |
50.0 ± 12.95 |
60.7 ± 20.82 |
71.5 ± 19.72 |
83.0 ± 21.85 |
92.8 ± 11.05 |
100.0 ± 15.1 |
111.1 ± 18.6 |
121.4 ± 11.76 |
121.4 ±15.9 |
114.3 ± 15.0 |
|
Test (C4/OLA) |
0.4 ± 0.54 |
5.6 ± 2.91 |
11.3 ± 5.83 |
18.5 ± 0.97 |
39.4 ± 4.16 |
54.1 ± 0.31 |
62.6 ± 1.44 |
52.7 ± 9.29 |
42.6 ± 0.39 |
36.2 ± 4.39 |
21.2 ± 2.68 |
15.6 ± 0.82 |
2.5 ± 2.49 |
0.37 ± 0.54 |
|
% inhibition of Edema with respect to control | ||||||||||||||
| Test (C4/OLA) | 88.80 | 60.78 | 68.36 | 56.78 | 21.20 | 10.87 | 12.45 | 36.51 | 54.09 | 63.80 | 80.92 | 87.15 | 97.94 | 99.68 |