Table 5.
Crystallization summary of drug loaded silicone patches with or without solubilizers
| Formulation code | Drug concentration | Solubilizers concentration | Patch Observation after 10 days | Solution observation after 10 days |
|---|---|---|---|---|
|
DS3 |
0.5% |
- |
No sign of crystallization |
Same as first day |
|
DS3 |
1% |
- |
No sign of crystallization |
Same as first day |
|
DS3E3 |
2% |
3% PEG-400 |
No sign of crystallization |
Oil globules were formed and the solution turned oily |
|
DS6E4 |
1% |
3% PEG-400 |
No sign of crystallization |
Oil globules were formed and the solution turned oily |
|
DS3G2 |
2% |
5% PG |
No sign of crystallization. |
Oil globules were formed and the solution turned oily |
|
DS3G3 |
1% |
2% PG |
No sign of crystallization. |
Oil globules were formed and the solution turned oily |
|
DS3O3 |
1% |
2% OLA |
Crystallization was seen. |
Same as first day |
|
DS3I3 |
1% |
2% ISA |
Crystallization was seen. |
Same as first day |
| DS3O4I4 | 3% | 5% OLA & 5% ISA | Crystallization was seen. | Same as first day |