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Solubility of drug in combinational patches
| Formulation code | Ratio of Silicone: Acrylic | Targeted drug concentration | Solubility observation |
|---|---|---|---|
| C1 |
10: 90 |
10% |
YES |
| C2 |
20: 80 |
10% |
YES |
| C3 |
30: 70 |
10% |
YES |
| C4 |
40: 60 |
10% |
YES |
| C5 |
50: 50 |
10% |
YES |
| C6 |
60: 40 |
10% |
NO |
| C7 |
70: 30 |
10% |
NO |
| C8 |
80: 20 |
10% |
NO |
| C9 | 90: 10 | 10% | NO |
C: combination patches with Acrylic and Silicone adhesives.
