Table 3.
Association between individual SNPs and MDS
| SNP | Genotype | Controls N (%) | Cases N (%) | OR (95% CI) | p-Values |
|---|---|---|---|---|---|
|
rs13240966 |
SLC4A2 |
235 |
173 |
|
|
| |
GG |
72 (30.64) |
22(12.72) |
1.0 (Ref) |
|
| |
CC |
64 (27.23) |
95 (57.91) |
4.86 (2.74-8.62) |
< 0.0001 |
| |
CG |
99 (42.13) |
56 (32.37) |
1.85 (1.04-3.30) |
0.04 |
| |
CC + CG |
163 (69.36) |
151 (87.28) |
3.03 (1.79-5.13) |
< 0.0001 |
|
rs2235074 |
ABCB1 |
261 |
188 |
|
|
| |
GG |
232 (88.55) |
129 (68.62) |
1.0 (Ref) |
|
| |
AA |
1 (0.38) |
0 (0.00) |
NA |
|
| |
AG |
28 (10.69) |
59 (31.38) |
3.79 (2.30-6.24) |
< 0.0001 |
| |
AA + AG |
29 (11.07) |
59 (31.38) |
3.66 (2.23-6.00) |
< 0.0001 |
|
rs20580 |
LIG1 |
264 |
191 |
|
|
| |
CC |
167 (63.26) |
84 (43.98) |
1.0 (Ref) |
|
| |
AA |
20 (7.58) |
33 (17.28) |
3.28 (1.77-6.06) |
< 0.0001 |
| |
AC |
77 (29.17) |
74(38.74) |
1.91 (1.26-2.89) |
0.002 |
| |
AA + AC |
97 (36.74) |
110 (57.59) |
2.25 (1.54-3.29) |
< 0.0001 |
|
rs574664 |
ROS1 |
262 |
189 |
|
|
| |
TT |
191 (72.90) |
95 (50.26) |
1.0 (Ref) |
|
| |
AA |
4 (1.53) |
4 (2.12) |
2.01 (0.49-8.22) |
0.32 |
| |
TA |
67 (25.57) |
90 (47.62) |
2.70 (1.81-4.03) |
< 0.0001 |
| |
AA + TA |
71 (27.10) |
94 (49.74) |
2.66 (1.79-3.95) |
< 0.0001 |
|
rs732417 |
STK6 |
257 |
188 |
|
|
| |
GG |
203 (78.99) |
113 (60.11) |
1.0 (Ref) |
|
| |
CC |
0 (0.00) |
2 (1.06) |
NA |
|
| |
CG |
54 (21.01) |
73 (38.83) |
2.43 (1.60-3.70) |
< 0.0001 |
| |
CC + CG |
54 (21.01) |
75 (39.89) |
2.50 (1.61-3.88) |
< 0.0001 |
|
rs1042838 |
PGR |
253 |
189 |
|
|
| |
GG |
174 (68.77) |
86 (45.50) |
1.0 (Ref) |
|
| |
TT |
2 (0.79) |
3 (1.59) |
3.04 (0.40-26.49) |
0.34 |
| |
TG |
77 (30.43) |
100 (52.91) |
2.63 (1.74-3.97) |
< 0.0001 |
| |
TT + TG |
79 (31.23) |
103 (54.50) |
2.64 (1.75-3.98) |
< 0.0001 |
|
rs8177426 |
GPX3 |
260 |
171 |
|
|
| |
GG |
155 (59.62) |
82 (47.95) |
1.0 (Ref) |
|
| |
AA |
14 (5.38) |
33(19.30) |
4.46 (2.16-9.32) |
< 0.0001 |
| |
AG |
91 (35.00) |
56 (32.75) |
1.16 (0.74-1.82) |
0.51 |
| |
AA + AG |
105 (40.38) |
92 (53.80) |
1.66 (1.10-2.47) |
0.01 |
|
rs11226 |
RAD52 |
234 |
171 |
|
|
| |
CC |
(61.11) |
83 (48.54) |
1.0 (Ref) |
|
| |
TT |
17 (7.26) |
32 (18.71) |
3.24 (1.62-6.53) |
0.0002 |
| |
TC |
74 (31.62) |
56 (32.75) |
1.30 (0.82-2.07) |
0.26 |
| |
TT + TC |
91 (38.88) |
90 (52.63) |
1.70 (1.15-2.54) |
0.01 |
|
rs3797896 |
MSH3 |
262 |
191 |
|
|
| |
CC |
232 (88.21) |
186 (97.38) |
1.0 (Ref) |
|
| |
GG |
3 (1.14) |
0 (0.00) |
NA |
|
| |
GC |
27 (10.27) |
5 (2.62) |
0.23 (0.09-0.61) |
0.001 |
| GG + GC | 30 (11.40) | 5 (2.62) | 0.21 (0.08-0.55) | 0.001 |