Figure 1.

Pho7 and Csk1 regulate a core set of genes induced in response to phosphate limitation. (A) Heat map showing the fold change (log₂ scale) of Pi-starvation induced genes in a wild-type background (first column), a pho7Δ strain in high- and no-Pi conditions vs. a pho7⁺ strain (second and third), a csk1Δ strain in high- and no-Pi conditions vs. a csk1⁺ strain (fourth and fifth), a pho7Δcsk1Δ strain in high- and no-Pi conditions vs. a pho7⁺csk1⁺ strain (sixth and seventh), and a csk1Δ strain in high- and no-Pi conditions vs. a pho7Δcsk1Δ strain (eighth and ninth) as measured by microarray analysis. Thresholds used for gene selection are described in the materials and methods. For a full list of Pi, pho7⁺, and csk1⁺ dependent genes see Additional file 3. (B) Pie chart showing the percentage of genes induced in response to Pi limitation with Pi- and Pho4-dependent orthologs in S. cerevisiae[7].