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. 2013 Jan 23;14:48. doi: 10.1186/1471-2164-14-48

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Copyright ©2013 Faulk et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CoBRA design. For each candidate locus we amplify a portion of the antisense strand of the 5′ LTR and unique flanking sequence (arrows) containing a BceAI recognition site. (A) The product of IAP236 is shown with cut sites and CpGs indicated by numbers 1–4. Sites 2 and 3 are conserved in all candidate loci and cut. PCR primers are underlined. (B) Percent methylation is derived from relative intensity of the cut vs. uncut bands. This locus exhibits an 18% range in variable methylation. Controls are shown in lanes 1 and 2, indicating the specificity and completeness of the digestion.