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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Oct 12;1828(7):1629–1643. doi: 10.1016/j.bbamem.2012.10.004

Figure 5.

Figure 5

Trafficking-mediated modulation of CaV2.2 channels due to direct interaction with GPCRs. (A) Nociceptin receptors (NOP) interact directly with the Cav2.2 α1 subunit via their C-termini. D1 and D2 receptors also interact with additional regions of the α1 subunit such as the domain II-III linker. Coexpression of these GPCRs with CaV2.2 facilitates trafficking of the channels to the plasma membrane, and the D1 receptor appears to target N-type channels to dendritric sites in prefrontal cortex [222]. (B) Prolonged NOP agonist application has been reported to promote co-internalization of the receptor/channel complex into lysosomes in cultured sensory neurons, thus giving rise to a new form of voltage-independent inhibition [220] (but see [221]).