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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Oct 12;1828(7):1629–1643. doi: 10.1016/j.bbamem.2012.10.004

Figure 6.

Figure 6

Alternative splicing of CaV2.2 controls voltage-independent inhibition of N-type ICa in sensory neurons. Two mutually exclusive forms of exon 37 encode the proximal C-terminus of CaV2.2. Expression of exon 37a is restricted to dorsal root ganglia, preferentially in nociceptive neurons, while exon 37b is widely expressed throughout the nervous system [254]. Gβγ-mediated, voltage-dependent inhibition of ICa is identical in channels containing either isoform of exon 37. An additional Gα-mediated, voltage-independent pathway involving pp60c-src tyrosine kinase inhibits channels containing exon 37a but not exon 37b. Thus alternative splicing of CaV2.2 results in cell-type specific alteration in the magnitude and mechanisms of GPCR-mediated inhibition.