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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Dec 13;1833(3):686–697. doi: 10.1016/j.bbamcr.2012.12.004

FIGURE 2. Nε-lysine acetylation in the lumen of the ER.

FIGURE 2

A, The ER membrane transporter AT-1 ensures a continuous supply of acetyl-CoA into the ER lumen while ER-membrane anchored acetyltransferases (ATase1 and ATase2) catalyze the transfer of the acetyl group to seven lysine residues of BACE1.

B, Covalent modification of the Nε-amino group of a lysine residue by acetylation.