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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Dec 13;1833(3):686–697. doi: 10.1016/j.bbamcr.2012.12.004

FIGURE 4. Schematic view of BACE1 acetylation.

FIGURE 4

Nascent BACE1 is transiently acetylated in the lumen of the ER by ATase1 and ATase2. If acetylated, nascent BACE1 can reach the Golgi apparatus and complete maturation. In contrast, non-acetylated BACE1 is retained and degraded in the ERGIC. The ER-based acetylation also requires translocation of acetylCoA from the cytosol into the lumen of the ER by the ER membrane transporter AT-1. The acetyl group is shown as a red circle.