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. Author manuscript; available in PMC: 2014 Feb 4.
Published in final edited form as: Vaccine. 2012 Dec 25;31(7):1072–1079. doi: 10.1016/j.vaccine.2012.12.033

Figure 1.

Figure 1

Endpoint titer of total OVA specific IgG in sera (A). Mice (8 animals per group) were immunized on day 0 and then three times, two weeks apart. Sera were collected every two weeks. Each additional immunization increased the endpoint titer. Two weeks after the fourth immunization, there was no further increase in endpoint titer (data not shown). Data shown are representative of one of three independent experiments. * - significant difference (p<0.005) in endpoint titer of IgG between groups OVA+NE and OVA+PBS; ** - significant difference (p<0.005) in endpoint titer of IgG between week 2 and week 4 and week 4 and week 6. Endpoint titer of IgG1, IgG2b and IgG2c subclasses of OVA specific antibodies (B). Data shown are representative of one of three independent experiments. * - significant difference (p<0.05) in endpoint titer of IgG1 between week 2 and 4; ** - significant difference (p<0.005) in endpoint titer of IgG2b between week 2 and 4.