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Cell velocity versus fibronectin density on mixed E-cadherin–fibronectin substrata. On these substrata, cadherin was fixed at 210 molecules/µm2, and the fibronectin density varied. Data are for parental 231 (filled squares) and 231Tet cells induced with 1 µg/ml and 100 µg/ml doxycycline (filled triangles and filled circles, respectively). As a control, 1 µg/ml doxycycline induced 231Tet cells were incubated with E-cadherin antibodies for 30 minutes prior to seeding (open triangles).
