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. Author manuscript; available in PMC: 2013 Jan 26.
Published in final edited form as: Nat Med. 2010 Feb 28;16(3):279–285. doi: 10.1038/nm.2092

Fig. 1. IDO pathway contributes to the regulation of BP in PbA-infected mice.

Fig. 1

(a-c) Expression of IDO in endothelial cells of resistance arteries in kidney. IDO expression was assessed by immunohistochemistry in non-infected mice and in mice 5 days post-infection with PbA (bar = 40 μm). IDO was expressed strongly in endothelial cells of PbA-infected mice (a) but was absent in non-infected mice (b) and in corresponding isotype control sections of PbA-infected mice (c). (d) Decreased plasma Trp and (e) increased Kyn concentration in PbA-infected Ido+/+ not Ido-/- mice. (f-g) SBP determined by tail cuff method in conscious C57BL/6J wild type (f) or Ido-/- (g) mice with or without PbA infection, before and after i.p. injection of 1 mL 20 mM 1-Me-Trp. Results in d-g represent mean±SEM, with the number of animals (N) used for each treatment indicated. *P<0.05 versus uninfected control (d, f) or before 1-Me-Trp injection in PbA-infected mice (g).