Figure 4.

(A) Scatter plot of partition score H_ijand modularity score V_ijfor all reaction pairs [i, j] in the Day 12 flux-weighted model. A red box is drawn around reaction pairs with H_ij > 0.7 and V_ij > 3.0. (B) Heat map showing the number of models (Day 4, Day 12, Day 12 with LDH inhibition, Day 12 with PCX inhibition) for which a reaction pair [i, j] has a high partition score and a high modularity score (H_ij > 0.7 and V_ij > 3.0). A reaction pair was designated as robust if H_ij > 0.7 and V_ij > 3.0 in all four models. The robust reaction pairs are shown as black squares in the heat map. (C) Scatter plot of partition score H_ij and modularity score V_ij for all reaction pairs [i, j] in the un-weighted model. The red asterisks denote the 17 robust reaction pairs identified in panel (B).