Table 2.

Association between Observer-rated (CTCAE) Toxicities or objective measures (VF scores or stimulated saliva) and overall patient-reported QOL: for all post-therapy and for late (≥6 and ≥12 months) data

Variable	Pearson Correlation Coefficient for all data	p-value for Correlation for all data	Parameter Estimate for all data	Pearson Correlation Coefficient for ≥ 6 month data	p-value for Correlation for ≥ 6 month data	Parameter Estimate for ≥ 6 month data	Pearson Correlation Coefficient for ≥ 12 month data	p-value for Correlation for ≥ 12 month data	Parameter Estimate for ≥ 12 month data
“Overall Bother”
CTCAEDysphagia	0.49	0.0005	3.0	0.44	<0.00001	4.0	0.33	0.01	3.0
CTCAEXerostomia	0.26	0.02	2.0	0.25	0.10	1.0	0.23	0.01	3.0
CTCAEVoice	0.06	NS	3.0	0.06	NS	3.0	0	n/a	0
CTCAEmucosa	0.35	0.01	2.0	0.33	0.009	3.0	0.19	0.05	3.0
CTCAEskin	0.03	0.005	4.0	0.21	0.01	3.0	0.15	0.03	4.0
CTCAEfibrosis	0.19	0.02	4.0	0.19	0.02	4.0	0.19	0.03	4.0
CTCAEL'hermitte's	0.17	NS	2.0	0.17	NS	2.0	0.20	NS	1.0
VF score	0.16	NS	2.0	0.16	NS	2.0	0.16	NS	2.0
Total	-0.23	NS	-4.0	-0.17	NS	-4.0	-0.15	NS	-5.0
Stimulated Saliva
Summary HNQOL Score
CTCAEDysphagia	0.53	<0.0001	5.2	0.51	<0.0001	5.0	0.50	<0.0001	7.3
CTCAEXerostomia	0.31	0.02	2.3	0.30	0.01	2.9	0.26	<0.001	4.8
CTCAEVoice	0.18	0.04	7.0	0.09	NS	3.3	0	n/a	0
CTCAEmucosa	0.32	0.01	2.4	0.30	NS	2.2	0.23	0.01	4.4
CTCAEskin	0.02	NS	0.4	0.17	NS	2.9	0.04	NS	1.7
CTCAEfibrosis	0.08	NS	0.7	0.14	NS	2.1	0.09	NS	1.9
CTCAEL'hermitte's	0.12	NS	2.5	0.18	NS	3.3	0.16	NS	3.0
VF score	0.37	<0.0001	4.4	0.29	0.01	3.5	0.29	0.01	3.5
Total	-0.20	NS	-4.3	-0.12	NS	-3.8	-0.12	NS	-5.4
Stimulated Saliva
Summary UWQOL Score
CTCAEDysphagia	0.56	<0.0001	3.5	0.53	<0.001	3.3	0.57	<0.0001	5.6
CTCAEXerostomia	0.35	<0.001	2.4	0.32	NS	0.9	0.28	0.01	2.4
CTCAEVoice	0.17	0.02	5.3	0.11	NS	5.1	0	n/a	0
CTCAEmucosa	0.43	<0.0001	3.2	0.38	NS	0.9	0.37	0.02	2.9
CTCAEskin	0.04	NS	1.6	0.14	0.05	2.4	0.03	NS	2.4
CTCAEfibrosis	0.08	NS	1.3	0.14	NS	2.1	0.09	NS	1.5
CTCAEL'hermitte's	0.05	NS	1.4	0.11	NS	2.1	0.10	NS	0.5
VF score	0.44	0.0001	3.0	0.41	0.0001	4.4	0.41	<0.0001	4.4
Total	-0.21	NS	-3.2	-0.15	NS	-2.4	-0.14	NS	-2.7
Stimulated