Table 1.
Effects of amphetamine (AMPH) on task performance. Total trials were unaffected by any amphetamine dose. There was a trend towards a main effect of Amphetamine Dose to reduce total correct responses [F(3, 36) = 2.58, p = 0.07]. A main effect of Amphetamine Dose on premature responses before the prime was observed [F(3, 36) = 6.96, p < 0.001]; post hoc testing confirmed that premature responses were increased after each amphetamine dose compared to saline (p < 0.01 for 0.25 mg/kg, p < 0.001 for 0.5 mg/kg, p < 0.05 for 1 mg/kg).
Data were analyzed using one-way repeated measures ANOVA. Post hoc comparisons of significant effects were conducted using Newman-Keuls tests. Values are expressed as mean ± SEM.
saline | 0.25 mg/kg | 0.5 mg/kg | 1 mg/kg | |
---|---|---|---|---|
trials | 111.69 ± 7.01 | 116.85 ± 8.11 | 95.08 ± 12.72 | 98.00 ± 11.22 |
total correct responses | 40.23 ± 4.40 | 38.62 ± 3.47 | 31.38 ± 5.61 | 27.54 ± 4.52† |
premature responses | 8.00 ± 1.51 | 35.08 ± 6.93** | 40.69 ± 9.95*** | 26.23 ± 6.56* |
Asterisks (*p < 0.05, **p < 0.01, ***p < 0.001) denote significant differences and dagger symbol (†) denotes a trend toward difference compared with performance after saline administration.