Table 2.
Oxidative stress and morphometric variables.
| Variable | W | FFR | SHR | FFHR | FFHR + C | FFHR + T |
|---|---|---|---|---|---|---|
| NAD(P)H oxidase activity (counts/min/mg tissue) |
40.5 ± 6 | 133 ± 5* | 160 ± 9.1∗# | 297 ± 9.1∗#∧ | 142 ± 9.1∗∧∗∗ | 97 ± 2.1∗∧∗∗ |
| Arterial eNOS activity (dpm/mg/prot/min) |
85.0 ± 2 | 60.1 ± 2.6* | 80.0 ± 2.1 | 56.4 ± 5.7∗#∧ | 86.4 ± 1.1** | 84.6 ± 1.1** |
| TBARS (μmol/L) | 1 ± 0.1 | 2.2 ± 0.1* | 1.69 ± 0.1* | 2.8 ± 0.1∗#∧ | 1.03 ± 0.6#∧∗∗ | 0.73 ± 0.4#∧∗∗ |
| Relative heart weight (mg/100 g body weight) |
225 ± 4 | 290 ± 4* | 330 ± 1.8∗# | 400 ± 4∗#∧ | 262 ± 4** | 289 ± 4** |
| Myocardiocyte area (μm2) | 1682 ± 69 | 2066 ± 57* | 2222 ± 78∗# | 3242 ± 55∗#∧ | 1588 ± 55** | 2188 ± 35** |
| Media/Lumen ratio mesenteric arteries | 13.9 ± 0.3 | 10.2 ± 0.5* | 8.9 ± 0.6∗# | 8.45 ± 0.2∗# | 14.5 ± 5** | 9.5 ± 5** |
The above values correspond to stress oxidative and morphometrics variables.
Symbols indicate: *P < 0.001 versus WKY; ∧ P < 0.001 versus SHR; # P < 0.01 versus FFR; **versus FFHR.