Table 1.
Patient demographics and disease and treatment characteristics
|
Characteristic |
Overall |
Case group |
Control group |
P-value |
|---|---|---|---|---|
| 3,858,840 | 164,463 [%] | 3,694,377 [%] | ||
| With chronic kidney disease |
66,476 |
13,445 [8.18] |
53,031 [1.44] |
<.0001 |
| Without chronic kidney disease |
3,792,364 |
151,018 |
3,641,346 |
|
| Age group, years | ||||
| 50-59 |
1,750,009 |
54,586 [33.19] |
1,695,423 |
<.0001 |
| 60-69 |
1,097,797 |
50,413 [30.65] |
1,047,384 |
|
| 70-79 |
734,932 |
45,041 [27.39] |
689,891 |
|
| ≥80 |
276,102 |
14,423 [8.77] |
261,679 |
|
| Sex | ||||
| Male |
1,863,738 |
125,311 [76.19] |
1,738,427 [47.06] |
<.0001 |
| Female |
1,995,102 |
39,152 |
1,955,950 |
|
| Comorbidities | ||||
| Hypertension |
419,678 |
45,693 [27.8] |
373,985[10.1] |
<.0001 |
| Hyperlipidemia |
60,744 |
9,521 [5.8] |
51,223 [1.4] |
<.0001 |
| Smoking-related diagnosis |
262,913 |
17,183 [10.4] |
245,730 [6.7] |
<.0001 |
| Alcoholism-related diagnosis |
28,305 |
2,891 [1.8] |
25,414 [0.7] |
<.0001 |
| Uremia |
21,526 |
2,228 [1.4] |
19,298 [0.5] |
<.0001 |
| Charlson’s comorbidities Index score† | ||||
| 0 |
3,099,342 |
106,542 |
2,992,800 |
0.0336 |
| 1 |
494,593 |
35,179 |
459,414 |
|
| 2 |
178,885 |
14,215 |
164,670 |
|
| 3 |
50,181 |
5,264 |
44,917 |
|
| 4 |
16,497 |
1,858 |
14,639 |
|
| 5 |
5,752 |
659 |
5,093 |
|
| 6 |
2,360 |
261 |
2,099 |
|
| 7 |
1,269 |
101 |
1,168 |
|
| 8 |
6,321 |
204 |
6,117 |
|
| 9 |
2,384 |
100 |
2,284 |
|
| 10+ |
1,256 |
80 |
1,176 |
|
| Follow-up in years | ||||
| 0 |
63,220 |
2,682 |
60,538 |
- |
| 1 |
65,186 |
4,115 |
61,071 |
|
| 2 |
67,987 |
4,446 |
63,541 |
|
| 3 |
67,136 |
4,484 |
62,652 |
|
| 4 |
3,519,426 |
144,228 |
3,375,198 |
|
| 5 | 75,885 | 4,508 | 71,377 | |
†Mann-Whitney U test.