Table 3.
Hazard ratios of subsequent death from CVD (2005.1.1-2007.12.31)
|
Cox models |
Crude HR |
95%CI |
SE |
P-Value |
Adjusted HR* |
95%CI |
SE |
P-Value |
||
|---|---|---|---|---|---|---|---|---|---|---|
| Low | Up | Low | Up | |||||||
| Model 1 | ||||||||||
| Control group (without gout) |
1 |
- |
- |
- |
- |
1 |
- |
- |
- |
- |
| Case group (with gout) |
1.69 |
1.65 |
1.74 |
0.01 |
<.0001 |
1.10 |
1.07 |
1.13 |
0.01 |
<.0001 |
| Model 2 | ||||||||||
| Gout but no CKD |
1 |
- |
- |
- |
- |
1 |
- |
- |
- |
- |
| Gout plus CKD |
1.99 |
1.85 |
2.14 |
0.04 |
<.0001 |
1.40 |
1.29 |
1.51 |
0.04 |
<.0001 |
| Model 3 | ||||||||||
| Control without CKD |
1 |
- |
- |
- |
- |
1 |
- |
- |
- |
- |
| Control with CKD |
3.35 |
3.24 |
3.47 |
0.02 |
<.0001 |
1.74 |
1.68 |
1.81 |
0.02 |
<.0001 |
| Model 4 | ||||||||||
| Control without CKD |
1 |
- |
- |
- |
- |
1 |
- |
- |
- |
- |
| Control with CKD |
3.36 |
3.24 |
3.48 |
0.02 |
<.0001 |
1.76 |
1.70 |
1.82 |
0.02 |
<.0001 |
| Gout but no CKD |
1.62 |
1.58 |
1.67 |
0.01 |
<.0001 |
1.10 |
1.07 |
1.13 |
0.02 |
<.0001 |
| Gout plus CKD | 3.21 | 2.99 | 3.44 | 0.04 | <.0001 | 1.38 | 1.29 | 1.48 | 0.04 | <.0001 |
*Adjustments were made in these Cox models for gender, age, smoking and alcoholism-related diagnoses, hypertension, hyperlipidemia, atrial fibrillation and Charlson’s co-morbidity index (CCI) score. To avoid double-counting (over-adjustment), in subjects with chronic kidney disease, CCI score did not consider chronic renal failure as a comorbidity.
CVD cardiovascular disease; CI confidence interval; CKD chronic kidney disease. HR hazard ratio which was calculated by Cox proportional time-to-event survival analysis; SE standard error.