Table 1.

Interface core definitions from the literature

	Chakrabarti	Levy	Schärer
Core definitions	Residues with at least 1 atom with BSA/ASA(u)=1	Residues with rASA(u)>0.25 & rASA(c)<0.25	Residues with BSA/ASA(u)>0.95
Example bio interface: [PDB:1N8P] interface 1 (total BSA=1969 Å2)	26+27	24+24	4+3

Interface residues are those for which BSA>0, core residues are then a subset of those. The values of core residue sizes for a typical biological interface example chosen from one of the entries in DCbio are shown (the 2 numbers corresponding to first and second partner of the interface). BSA is defined as BSA=ASA(u)-ASA(c), relative ASA as rASA=ASA/ASA(GLY-X-GLY). u and c stand for uncomplexed and complexed respectively.