Table 1.
Association results derived from linear regression between 11 9p21.3-variants and severity of disease (defined as quantitative trait) in the Italian study (N=2,908)
| SNP | Position | Alleles | MAF | Beta | s.e. | P | Pemp |
|---|---|---|---|---|---|---|---|
| rs7044859 |
22,008,781 |
A/T |
0.463 |
0.015 |
0.025 |
5.46E-01 |
9.87E-01 |
| rs10965215 |
22,019,445 |
A/G |
0.435 |
0.029 |
0.024 |
2.31E-01 |
7.38E-01 |
| rs564398 |
22,019,547 |
C/T |
0.301 |
0.060 |
0.026 |
2.44E-02 |
1.34E-01 |
| rs7865618 |
22,021,005 |
A/G |
0.304 |
0.063 |
0.026 |
1.66E-02 |
9.44E-02 |
| rs10116277 |
22,071,397 |
G/T |
0.390 |
0.069 |
0.026 |
9.14E-03 |
5.90E-02 |
| rs4977574 |
22,088,574 |
A/G |
0.398 |
0.107 |
0.025 |
1.75E-05 |
4.00E-04 |
| rs2383207 |
22,105,959 |
A/G |
0.360 |
0.100 |
0.027 |
1.98E-04 |
1.50E-03 |
| rs10738610 |
22,113,766 |
A/C |
0.386 |
0.070 |
0.026 |
8.36E-03 |
5.30E-02 |
| rs10757278 |
22,114,477 |
A/G |
0.416 |
0.036 |
0.025 |
1.51E-01 |
5.62E-01 |
| rs1333049 |
22,115,503 |
C/G |
0.421 |
0.041 |
0.025 |
9.52E-02 |
4.01E-01 |
| rs10811661 | 22,124,094 | C/T | 0.206 | 0.033 | 0.031 | 2.88E-01 | 8.22E-01 |
Boldface allele denotes coded allele; MAF, minor allele frequency; Genetic effects (betas) adjusted according to severity of CAD ~ age+sex+T2D + SNP. Boldface P value denotes statistical nominal significance <0.05; Pemp denotes empirical significance derived from 10,000 permutations on the 9p21.3 region including the 11 SNPs tested.