Table 3.

Replication results; Association results derived from logistic regression between rs4977574 and severity of CAD without T2D in Italian (N=2,343) and Canadian studies (N=950)

		EO CAD
		OR (95% CI)	P
3VD vs. (2VD+1VD)
rs4977574	Italian	1.734 (1.142-2.633)	9.77E-03
	Canadian	1.381 (1.124-1.698)	2.14E-03
1VD vs. (2VD+3VD)
rs4977574	Italian	0.721 (0.542-0.958)	2.42E-02
	Canadian	0.648 (0.527-0.795)	3.28E-05

Odds ratio (OR) adjusted for age and sex; 05 CI, 95% confidence interval of OR; Boldface P denotes nominal P value significance <0.05; EO, early-onset CAD; 1VD=1-vessel disease; 2VD=2-vessel disease; 3VD=3-vessel disease.