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. Author manuscript; available in PMC: 2013 Jan 27.
Published in final edited form as: Neurosci Lett. 2011 Sep 16;504(2):102–106. doi: 10.1016/j.neulet.2011.09.007

Fig 1.

Fig 1

Activation of group II mGlus induces long-term depression of excitatory transmission in the SNr. (A) Time course of the EPSC amplitude following 10 minute bath application of LY379268 (10-100 nM) shows that induction of LTD by LY379268 is concentration-dependent. Data represent mean ± SEM for 6-14 cells per drug treatment. Representative sample traces from a single experiment with 100nM LY379268 were taken from time points indicated by numbers and are the average of 6 individual traces. (B) Pre-incubation of slices with the mGlu2/3 antagonist LY341495 (500 nM, 10 minutes prior to LY379268 application) blocks induction of LTD (n = 5).