Figure 6.
Glycine labelling differs from phenylalanine. Comparison of glycine and phenylalanine carbons from labelling experiments (n = 3, SD). Glycine and the first two carbons of phenylalanine are derived in part from three carbon intermediates including 3-phosphoglycerate and phosphoenolpyruvate. (a) Glycine shows different mass enrichments between large subunits (LSUs) and small subunits (SSUs), (b) while phenylalanine is enriched similarly in both. (c) Glycine is significantly labelled by [U-13C]-glutamine whereas phenylalanine is unlabelled. (d) Glucose labelling reveals differences between glycine and phenylalanine that are derived from different metabolic processes.