Table 2.
Selected Gene Ontology terms and InterPro domains enriched among differentially expressed genes
| Differentially expressed (729 genes) | Upregulated (485 genes) | Downregulated (254 genes) | ||||
|---|---|---|---|---|---|---|
| Genes | P | Genes | P | Genes | P | |
| Biological process Gene Ontology terms | ||||||
| Immune response | 70 | 2.4 × 10-12 | 61 | 3.0 × 10-16 | 9 | NS |
| Nervous system development | 106 | 1.9 × 10-10 | 62 | 0.0055 | 44 | 2.3 × 10-5 |
| Cell adhesion | 74 | 9.8 × 10-8 | 56 | 1.9 × 10-7 | 18 | NS |
| Antigen processing and presentation | 17 | 4.3 × 10-7 | 17 | 5.4 × 10-10 | 0 | NS |
| Cell differentiation | 128 | 7.4 × 10-7 | 74 | NS | 54 | 1.8 × 10-4 |
| Cell migration | 44 | 3.0 × 10-4 | 30 | 0.0262 | 14 | NS |
| Cell proliferation | 86 | 3.4 × 10-4 | 59 | 0.0136 | 27 | NS |
| Cellular ion homeostasis | 36 | 0.0138 | 33 | 1.7 × 10-5 | 3 | NS |
| Molecular function Gene Ontology terms | ||||||
| Cytokine activity | 27 | 2.3 × 10-8 | 25 | 7.1 × 10-11 | 2 | NS |
| Signal transducer activity | 111 | 2.8 × 10-7 | 66 | 0.0584 | 45 | 0.0017 |
| Receptor activity | 83 | 8.0 × 10-7 | 48 | NS | 35 | 0.0016 |
| Sequence-specific DNA binding | 52 | 2.7 × 10-4 | 34 | 0.0526 | 18 | NS |
| MHC class II receptor activity | 5 | 0.0077 | 5 | 9.2 × 10-4 | 0 | NS |
| Growth factor activity | 20 | 0.0109 | 17 | 0.0019 | 3 | NS |
| InterPro domains | ||||||
| Immunoglobulin-like | 45 | 3.1 × 10-8 | 32 | 6.0 × 10-6 | 13 | NS |
| MHC classes I/II-like antigen recognition protein | 14 | 1.1 × 10-7 | 14 | 3.2 × 10-10 | 0 | NS |
| Homeobox | 28 | 8.5 × 10-6 | 18 | 0.0124 | 10 | NS |
Number of genes differentially expressed at 10% FDR and annotated with the indicated Gene Ontology and InterPro terms. P-values indicating the statistical significance of enrichment of these terms were computed with Fisher's exact test and corrected for multiple testing using the Bonferroni method. NS, not significant (P > 0.1).