Table 3.
Representative KEGG pathways from signaling pathway impact analysis of gene expression differences between GNS and NS cell lines
| Pathway | Genes | P | Predicted status in GNS cells |
|---|---|---|---|
| Cytokine-cytokine receptor interaction | 29 | 4.4 × 10-12 | Activated |
| Chemokine signaling pathway | 15 | 5.3 × 10-6 | Activated |
| Neuroactive ligand-receptor interaction | 21 | 2.2 × 10-4 | Inhibited |
| Antigen processing and presentation | 11 | 6.8 × 10-4 | Activated |
| MAPK signaling pathway | 24 | 0.0106 | Activated |
| Glioma | 10 | 0.0131 | Activated |
| ECM-receptor interaction | 10 | 0.0405 | Inhibited |
| Calcium signaling pathway | 15 | 0.0405 | Activated |
The number of genes found to be differentially expressed at 10% FDR and belonging to the selected pathways are indicated. P-values and status predictions were obtained by signaling pathway impact analysis [26], taking fold-change estimates and pathway topology into account. P-values were FDR-corrected for multiple testing. ECM, extracellular matrix; MAPK, mitogen-activated protein kinase.