Table 4.
Novel candidate glioma genes identified by differential expression and pathway analysis
| Genea | Log2 fold-changeb | Prior association with glioma | Implication in other neoplasms | Reference |
|---|---|---|---|---|
| CACNA1A | 7.1 | None | Prostate cancer (mouse model) | [80] |
| CACNA1C | -8.2 | None | Liver cancer | [81] |
| CACNG7 | -2.6 | None | None | -- |
| CACNG8 | -4.8 | None | None | -- |
| CAMK1D | -2.4 | None | Breast cancer | [82] |
| CPLX2 | 6.4 | None | None | -- |
| DDIT3 (CHOP, GADD153) | 4.4 | Limited | General (cellular stress response) | [83-86] |
| DUSP16 | 4.2 | None | Burkitt's lymphoma | [87] |
| FGF19 | - | None | Liver, lung and colon cancer | [88] |
| ITGA4 (CD49D) | 3.0 | Limited | Chronic lymphocytic leukemia, breast cancer and others | [89-91] |
| ITGBL1 | + | None | None | -- |
| MAP3K5 (ASK1) | 5.1 | Limited | Gastric cancer and histiocytoma | [92-94] |
| NFATC2 (NFAT1) | + | Limited | Breast cancer | [95-98] |
| NFKBIZ | 5.1 | None | Liposarcoma | [99] |
| NR0B1 (DAX1) | + | None | Lung adenocarcinoma and Ewing's sarcoma | [100,101] |
| NR1D1 | 2.9 | None | Breast cancer | [102] |
| PARP3, PARP12 | 4.1, 2.9 | By homologyc | The PARP gene family is involved in DNA repair and several other processes related to tumorigenesis | [103,104] |
| PERP | 3.8 | None | Lung and skin cancer | [105,106] |
| PPEF1 | 4.4 | Limited | None | [107] |
| SNAP25 | 3.3 | None | Lung cancer | [108] |
| SYT1 | -2.5 | None | None | -- |
| TNFRSF14 | 4.0 | None | Follicular lymphoma | [109] |
| TNFSF4 (OX40L) | 4.0 | None | Generally implicated in immune response to tumors | [110] |
aAliases are listed in parentheses. bGene expression log2 fold-change between GNS and NS cell lines compared by Tag-seq. Some genes were detected exclusively in GNS or NS cells (indicated in column 2 by + or -, respectively). cThe homolog PARP1 has been implicated in glioma. PARP, poly(ADP-ribose) polymerase.