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. Author manuscript; available in PMC: 2013 Jan 28.
Published in final edited form as: Neuropharmacology. 2011 May 27;61(4):770–777. doi: 10.1016/j.neuropharm.2011.05.023

Fig. 5.

Fig. 5

5-HT2AR-D2R heteromer crosstalk hypothesis: effects of D2R expression and activation on 5-HT2AR binding and signaling properties. On the left, serotonin 5-HT2AR is illustrated as binding its agonist DOI and being coupled to Gq/11 protein. In the middle, dopamine D2R expression might have an allosteric effect (illustrated with a white arrow) on 5-HT2AR by decreasing DOI agonist affinity to 5-HT2AR and increasing 5-HT2AR coupling to Gq/11 protein. In contrast, on the right, D2R activation (induced by its agonist quinpirole) leads to an increased affinity of 5-HT2AR for DOI and a decreased Gq/11 protein coupling to 5-HT2AR.