Table 2.
Minimum inhibitory concentration/minimum fungicidal concentration (MIC/MFC) (in mg/ml) of the crude extract of Coula edulis stem bark and fractions and compounds isolated from the extract against the tested dermatophytes.
| Test samples | M. audouinii | M. gypseum | T. terrestre | T. mentagrophytes | E. floccoseum |
|---|---|---|---|---|---|
| Crude extract | 1.25 / 1.25 | 2.50 / 2.50 | 5 / 5 | 1.25 / 1.25 | 2.50 / 2.50 |
| Fraction F1 | >5 / >5 | >5 / >5 | >5 / >5 | >5 / >5 | 2.50 / >5 |
| Fraction F2 | 1.25 / 1.25 | 2.50 / >5 | 5 / >5 | 5 / >5 | 1.25 / 2.50 |
| Fraction F3 | 0.62 / 1.25 | 2.50 /2.50 | 1.25 / 1.25 | 1.25 / 1.25 | 0.62 / 1.25 |
| Fraction F4 | 1.25 / 2.50 | >5 / >5 | >5 / >5 | >5 / >5 | 2.50 / 2.50 |
| Fraction F5 | 2.50 / 5 | >5 / >5 | >5 / >5 | >5 / >5 | 2.50 / 5 |
| Fraction F6 | 2.50 / 5 | >5 / >5 | >5 / >5 | >5 / >5 | 2.50 / 5 |
| Fraction F7 | 2.50 / 5 | >5 / >5 | >5 / >5 | >5 / >5 | >5 / >5 |
| Fraction F8 | 2.50 / 5 | >5 / >5 | >5 / >5 | >5 / >5 | >5 / >5 |
| Compound 1 | 0.40 / 0.40 | nt | nt | Nt | 0.20 / 0.20 |
| Compound 2 | 0.80 / >0.80 | nt | nt | Nt | 0.80 / >0.80 |
| Griseofulvin | 0.001 / >0.10 | 0.01 / > 0.10 | 0.020 / > 0.10 | 0.001 / > 0.10 | 0.001 / >0.10 |
M; Microsporum, T: Trichophyton, E: Epidermophyton.1: 3-O-β-D-glucopyranoside of sitosterol; 2: β-sitosterol, stigmasterol and n-hexadecanoid acid. Nt; not tested