Table 2.
Early and late ischemia-induced release of GABA, glutamate, and taurine.
7-day-old mice | 3-month-old mice | |||
---|---|---|---|---|
Amino acid | mmol/min/kg protein | mmol/min/kg protein | ||
Release period | Release period | |||
20–30 min | 32–50 min | 20–30 min | 32–50 min | |
Cerebral cortex | ||||
GABA | 0.108 ± 0.002 | 0.104 ± 0.001 | 0.429 ± 0.007 | 0.235 ± 0.024* |
Glutamate | 0.282 ± 0.010 | 0.171 ± 0.012* | 0.671 ± 0.057 | 0.870 ± 0.015* |
Taurine | 3.357 ± 0.164 | 2.078 ± 0.100* | 1.112 ± 0.061 | 1.050 ± 0.038 |
Cerebellum | ||||
GABA | 0.055 ± 0.001 | 0.051 ± 0.001 | 0.384 ± 0.020 | 0.265 ± 0.011* |
Glutamate | 0.044 ± 0.001 | 0.046 ± 0.001 | 0.229 ± 0.029 | 0.082 ± 0.014* |
Taurine | 0.859 ± 0.028 | 0.933 ± 0.022 | 0.826 ± 0.015 | 0.687 ± 0.018* |
The average release rates (±SEM) were calculated for the release periods indicated. Number of independent experiments 8 and release estimates 5 (20–30 min) and 10 (32–50 min). Significance of differences between the early and late release periods: *P < 0.01.