Table 3.
Genotype frequency (%), adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between adenosine receptor A2A (ADORA2A) and cytochrome P450 1A2 (CYP1A2) polymorphisms and Parkinson’s disease in PEGASUS.
| Overall | White, non-Hispanic | |||||||
|---|---|---|---|---|---|---|---|---|
| Variant | Cases (n=1325) |
Controls (n=1735) |
ORa | 95% CI | Cases (n=1035) |
Controls (n=1279) |
ORb | 95% CI |
| ADORA2A | ||||||||
| rs5751876c | ||||||||
| CC | 35.7 | 32.3 | 1.00 | -- | 37.4 | 35.0 | 1.00 | |
| CT | 45.7 | 46.3 | 0.93 | 0.78– 1.1 | 45.6 | 48.1 | 0.91 | 0.75–1.09 |
| TT | 18.7 | 21.4 | 0.85 | 0.69–1.05 | 17.0 | 16.8 | 0.93 | 0.73– 1.2 |
| rs3032740c | ||||||||
| TT | 36.5 | 32.6 | 1.00 | -- | 38.1 | 35.2 | 1.00 | -- |
| Td | 45.4 | 46.3 | 0.91 | 0.77– 1.07 | 45.4 | 48.1 | 0.89 | 0.74–1.08 |
| dd | 18.2 | 21.1 | 0.83 | 0.67–1.03 | 16.5 | 16.7 | 0.91 | 0.71– 1.18 |
| rs71651683 | ||||||||
| CC | 97.7 | 95.8 | 1.00 | -- | 97.6 | 96.1 | 1.00 | -- |
| CT | 2.3 | 4.2 | 0.53 | 0.34–0.83 | 2.4 | 3.8 | 0.61 | 0.36–1.02 |
| TT | 0.0 | 0.1 | 0.00 | NE | 0.0 | 0.1 | 0.00 | NE |
| rs5996696 | ||||||||
| AA | 93.0 | 90.0 | 1.00 | -- | 95.1 | 93.2 | 1.00 | -- |
| AC | 6.6 | 8.8 | 0.76d | 0.57–1.02 | 4.8 | 6.5 | 0.70e | 0.48–1.02 |
| CC | 0.4 | 1.2 | 0.37d | 0.13–1.01 | 0.1 | 0.2 | 0.30e | 0.03–2.93 |
| CYP1A2 | ||||||||
| rs762551 | ||||||||
| AA | 49.7 | 49.5 | 1.00 | -- | 51.4 | 51.1 | 1.00 | -- |
| AC | 40.1 | 41.4 | 0.99 | 0.85–1.16 | 39.6 | 40.4 | 0.99 | 0.83–1.19 |
| CC | 10.1 | 9.1 | 1.16 | 0.9–1.51 | 9.0 | 8.6 | 1.04 | 0.76–1.43 |
| rs2472304 f | ||||||||
| AA | 36.0 | 33.1 | 1.00 | 43.1 | 40.9 | 1.00 | ||
| AG | 42.3 | 43.8 | 0.93 | 0.78– 1.1 | 44.3 | 46.3 | 0.91 | 0.76– 1.1 |
| GG | 21.7 | 23.1 | 1.01 | 0.81–1.27 | 12.6 | 12.8 | 0.89 | 0.67–1.17 |
| rs2470890 f | ||||||||
| TT | 35.9 | 33.5 | 1.00 | -- | 43.4 | 41.1 | 1.00 | -- |
| TC | 42.3 | 43.5 | 0.95 | 0.8–1.12 | 44.2 | 46.1 | 0.92 | 0.76– 1.1 |
| CC | 21.8 | 23.1 | 1.02 | 0.81–1.28 | 12.4 | 12.8 | 0.88 | 0.67–1.16 |
NE = not estimable
a
Adjusted for age, sex, site, and race/ethnicity
b
Adjusted for age, sex and site
c
rs5751876 and rs3032740 were in strong linkage disequilibrium (D'=.997 and r2=0.98)
d
p for trend=0.01, permutation-adjusted p for trend = 0.04
e
p for trend=0.03, permutation- adjusted p for trend = 0.1
f
rs2470890 and rs2472304 were in strong linkage disequilibrium (D'=.993, r2 =.986)