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. Author manuscript; available in PMC: 2013 Jan 28.
Published in final edited form as: Dev Neurobiol. 2011 Jan 1;71(1):45–61. doi: 10.1002/dneu.20853

Figure 1.

Figure 1

Distribution of three groups of GABAergic interneurons in S1 cortex. Shown are the proportions of GAD-67 mRNA-expressing neurons also expressing mRNA for parvalbumin (PV), somatostatin (SST), or 5HT3aR based on the study by Lee et al. (2010). PV-expressing interneurons (including those expressing SST mRNA) account for ~40% of the total GABAergic population in the mouse S1 cortex. SST-expressing and 5HT3aR-expressing neurons account for ~30% each. The distribution of interneuron groups varies among different cortical layers. 5HT3aR neurons are concentrated in supragranular layers. Layer I, which has a much lower cell density, expresses mainly 5HT3aR neurons. In layer I and in layers II/III, the proportion of 5HT3aR neurons exceeds the proportion of PV cells. The proportion of PV cells is particularly large in layer IV. There are no PV neurons in layer I. SST interneurons are found in all layers, but are particularly abundant in infragranular layers.