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. 2013 Jan;15(1):39–48. doi: 10.1593/neo.121362

Figure 5.

Figure 5

Knockdown of MALT1 sensitizes MCF7 and HeLa to cisplatin. (A) Knockdown of MALT1 by siRNA in MCF7 increased cisplatin-induced apoptosis as detected by Caspase-8/7 and PARP cleavage. HECTD3 siRNA was used as the positive control. (B) Knockdown of MALT1 by siRNA in HeLa increased cisplatin-induced apoptosis as detected by Caspase-8/3/7 and PARP cleavage. (C) Knockdown of MALT1 by siRNA in MCF7 significantly increased cisplatin-induced loss of cell viability as measured by SRB assays. MALT1 is a weaker pro-survival protein compared to HECTD3. (D) Knockdown of MALT1 by siRNA in HeLa significantly increased cisplatin-induced loss of cell viability as measured by SRB assays.