Table 3.
Hazard ratio estimates for distal recurrence and death for sequential models.
| Characteristics | Model 1 | Model 2 | Model 3 | Model 4 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
| Index of Relative Socio-economic Disadvantage | ||||||||||||
| Lowest IRSD | Ref. | 0.83§ | Ref. | 0.81§ | Ref. | 0.96§ | ||||||
| Quintile 2 | 1.07 | 0.75, 1.53 | 0.7 | 1.03 | 0.72, 1.48 | 0.85 | 1.09 | 0.75, 1.61 | 0.6 | |||
| Quintile 3 | 1.00 | 0.70, 1.43 | 1.0 | 0.97 | 0.67, 1.39 | 0.85 | 1.00 | 0.68, 1.48 | 1.0 | |||
| Quintile 4 | 1.08 | 0.76, 1.54 | 0.7 | 1.13 | 0.79, 1.61 | 0.52 | 1.12 | 0.76, 1.64 | 0.6 | |||
| Highest IRSD | 0.88 | 0.60, 1.28 | 0.5 | 0.90 | 0.61, 1.32 | 0.59 | 1.00 | 0.67, 1.49 | 1.0 | |||
| Education | ||||||||||||
| Incomplete High school | Ref. | 0.04§ | Ref. | 0.55§ | Ref. | 0.3§ | ||||||
| High school | 1.38 | 1.03, 1.85 | 0.03 | 1.15 | 0.85, 1.55 | 0.36 | 1.19 | 0.86, 1.65 | 0.3 | |||
| University | 1.51 | 1.08, 2.13 | 0.02 | 1.20 | 0.85, 1.72 | 0.3 | 1.34 | 0.92, 1.96 | 0.1 | |||
| Age at diagnosis | ||||||||||||
| <35 years | Ref. | <0.001§ | Ref. | <0.01§ | ||||||||
| 35-39 years | 1.03 | 0.77, 1.38 | 0.9 | 1.05 | 0.76, 1.45 | 0.8 | ||||||
| 40-49 years | 0.56 | 0.39, 0.79 | <0.001 | 0.71 | 0.47, 1.08 | 0.1 | ||||||
| 50-59 years | 0.34 | 0.23, 0.51 | <0.001 | 0.47 | 0.28, 0.77 | |||||||
| <0.001 | ||||||||||||
| Tumour size | ||||||||||||
| <20 mm | Ref. | |||||||||||
| >20 mm | 1.43 | 1.10, 1.85 | 0.01 | |||||||||
| Tumour grade score | ||||||||||||
| 1 | Ref. | <0.01§ | ||||||||||
| 2 | 2.36 | 1.34, 4.16 | ||||||||||
| <0.001 | ||||||||||||
| 3 | 2.56 | 1.46, 4.48 | ||||||||||
| <0.001 | ||||||||||||
| Number of involved nodes | ||||||||||||
| 0 | Ref. | <0.001§ | ||||||||||
| 1 to 3 | 1.78 | 1.33, 2.37 | ||||||||||
| <0.001 | ||||||||||||
| >4 | 3.18 | 2.31, 4.38 | ||||||||||
| <0.001 | ||||||||||||
| Obese in year prior to diagnosis | ||||||||||||
| No | Ref. | |||||||||||
| Yes | 1.12 | 0.78, 1.63 | 0.5 | |||||||||
| Years since last pregnancy | ||||||||||||
| Nulliparous | Ref. | 0.09§ | ||||||||||
| <2 years | 1.56 | 0.98, 2.48 | 0.06 | |||||||||
| 2-4 years | 1.47 | 1.01, 2.15 | 0.05 | |||||||||
| >5 years | 1.07 | 0.75, 1.51 | 0.7 | |||||||||
| Number of cases included in the model | 1,029 | 1,029 | 1,029 | 940 | ||||||||
Model 1 includes the Index of Relative Socio-economic Disadvantage (IRSD) as the explanatory variable, without adjustment for any other factors. Model 2 includes highest level of education achieved as the sole explanatory variables. In Model 3, both measures of SES (IRSD and education level) are included as explanatory variables, as well as age at diagnosis. Model 4 includes both SES measures, age at diagnosis, and all other prognostic factors. H.R. denotes the hazard ratio and 95% C.I. indicates the 95% confidence interval for the hazard ratio point estimate.
§
indicates the overall significance of ordinal variables.