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. 2013 Jan 9;110(4):1446–1451. doi: 10.1073/pnas.1214608110

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Fig. 4. — Human cardiomyocytes show increased formation of polyploid nuclei between birth and 20 y. (A) Validation of LSC method for quantification of mononucleated cardiomyocytes. (B) In humans, the percentage of mononucleated cardiomyocytes remains unchanged after birth. (C) Tetraploid cardiomyocyte nucleus (DAPI, blue) with FISH probe against chromosome 8. Scale bar: 25 μm. (D) Comparison of quantification of nuclear DNA content using FISH and LSC shows significant correlation. (E) The percentage of polyploid mononucleated cardiomyocytes increases with age. (F) Percentage of cardiomyocytes with DNA content >2N determined by LSC increases with age. Statistical difference between 0–1 y and other age groups was tested with one-way ANOVA: *P < 0.05. n, number of hearts analyzed.