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. 2013 Jan 7;110(4):1428–1433. doi: 10.1073/pnas.1214994110

Fig. 6.

Fig. 6.

Viral titers in mice immunized with free MHV-68 peptides or αDEC205 sortagged with MHV-68 epitope library. The MHV-68 epitope library (Table S1, probe 29–47) was sortagged to αDEC205, and the desired product was purified as described in Fig. S1A. C57/BL6 mice were immunized with 20 μg of αDEC205-G3-FR-MHV-68 mix together with 25 μg of αCD40 and 50 μg of Poly I:C or an equimolar quantity of free MHV-68 peptide mix together with 25 μg of αCD40 and 50 μg of Poly I:C at 14 and 7 d before intranasal infection with 105 pfu of MHV-68. Histograms show pfu per gram of lung tissue in control mice (n = 8), mice immunized with free MHV-68 peptide (n = 7), or mice immunized with αDEC205-G3-FR-MHV-68 (n = 8) 6 d after infection. Errors bars show SDs (*P < 0.05, Student t test); representative of two independent experiments.