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Impact of Δfmt mutation on the folic acid pathway. (A) Consequences on folic acid metabolism of dihydrofolate reductase (DHFR) inhibition with trimethoprim and dihydropteroate synthetase (DHPS) inhibition with sulfamethoxazole. DHFS stands for dihydrofolate synthase. (B) MICs were determined for the indicated antibiotics. Data represent means ± SEM of at least three independent experiments. *P < 0.05; **P < 0.005; ***P < 0.001 as calculated by the two-tailed Student’s t-test.
