Table 2.
Summary ORs for various contrasts of XRCC3 Thr241Met gene polymorphisms in this meta-analysis
| Subgroup analysis |
exon7 genotype |
||
|---|---|---|---|
| Contrast studies OR(95%) Ph | |||
|
Total |
T/T vs C/C |
17 |
0.99(0.86-1.15) 0.315 |
| (C/T + T/T) vs C/C |
0.95(0.87-1.04) 0.228 |
||
| Ethnicity |
|
|
|
| Asian |
T/T vs C/C |
5 |
0.92(0.71-1.09) 0.216 |
| (C/T + T/T) vs C/C |
0.94(0.77-1.15) 0.545 |
||
| Caucasian |
T/T vs C/C |
10 |
0.94(0.87-1.13) 0.090 |
| (C/T + T/T) vs C/C |
0.95(0.85-1.06) 0.056 |
||
| Mixed population |
T/T vs C/C |
2 |
1.04(0.77-1.43) 0.190 |
| (C/T + T/T) vs C/C |
1.00(0.73-1.37) 0.823 |
||
|
Histological type |
|
|
|
| SCC |
T/T vs C/C |
2 |
0.94(0.78-1.58) 0.164 |
| (C/T + T/T) vs C/C |
0.91(0.48-1.74) 0.215 |
||
| AC |
T/T vs C/C |
3 |
1.09(0.72-1.38) 0.535 |
| (C/T + T/T) vs C/C |
1.05(0.79-1.40) 0.331 |
||
|
Smoking status |
|
|
|
| Smoker |
T/T vs C/C |
4 |
0.98(0.72-1.45) 0.006 |
| (C/T + T/T) vs C/C |
0.93(0.63-1.37) 0.001 |
||
| Non-smoker | T/T vs C/C |
4 | 0.99(0.78-1.51) 0.230 |
| (C/T + T/T) vs C/C | 0.92(0.62-1.37) 0.186 | ||
Ph P value of Q-test for heterogeneity test.