Table 1.
Characteristic phenotypes of HAB vs. LAB mice (F0 mice, N = 8 per gender and line); values are represented as mean ± standard error of means (SEM); corrected p-values refer to Bonferroni correction and are sorted by p-values of comparison in male mice
| Phenotype | HAB males mean±SEM | LAB males mean±SEM | p (males) | corrected p (males) | HAB females mean±SEM | LAB females mean±SEM | p (females) | correctedp (females) |
|---|---|---|---|---|---|---|---|---|
| EPM - percent time on the open arm |
4±1 |
74±2 |
0.0000 |
0.0000 |
6±1 |
61±6 |
0.0000 |
0.0011 |
| EPM - percentage of open arm entries |
17±2 |
63±4 |
0.0000 |
0.0000 |
20±3 |
53±6 |
0.0005 |
0.0115 |
| TST - total immobility time [s] |
113±10 |
4±1 |
0.0000 |
0.0002 |
112±11 |
7±3 |
0.0000 |
0.0010 |
| EPM - closed arm entries |
19±1 |
8±1 |
0.0000 |
0.0007 |
19±1 |
10±2 |
0.0020 |
0.0510 |
| EPM - full open arm entries |
0±0 |
13±2 |
0.0002 |
0.0049 |
0±0 |
9±1 |
0.0002 |
0.0060 |
| EPM - open arm entries |
4±1 |
13±2 |
0.0016 |
0.0461 |
5±1 |
11±2 |
0.0102 |
0.2555 |
| TST - latency to 1st immobility [s] |
101±5 |
232±28 |
0.0023 |
0.0633 |
105±12 |
235±40 |
0.0137 |
0.3423 |
| PHYS - total fluid intake [ml] |
6±1 |
11±1 |
0.0027 |
0.0746 |
NA |
NA |
NA |
NA |
| OF - total distance travelled [m] |
9±2 |
24±4 |
0.0042 |
0.1180 |
14±2 |
29±2 |
0.0003 |
0.0078 |
| PHYS - daily water intake [ml/g] |
0.22±0.03 |
0.36±0.03 |
0.0044 |
0.1231 |
NA |
NA |
NA |
NA |
| PHYS - urine osmolality [osmol/kg] |
2.9±0.2 |
2.3±0.2 |
0.0164 |
0.4595 |
NA |
NA |
NA |
NA |
| EPF - frequency of head dips |
4±2 |
12±3 |
0.0313 |
0.8760 |
4±2 |
14±6 |
0.1914 |
1.0000 |
|
HPA-RT - increase in CORT [μg/l] |
110±16 |
163±18 |
0.0360 |
1.0000 |
187±27 |
254±26 |
0.0995 |
1.0000 |
| EPM - latency to 1st open arm entry [s] |
87±24 |
27±5 |
0.0391 |
1.0000 |
118±30 |
52±12 |
0.0702 |
1.0000 |
| EPF - latency to 1st head dip [s] |
138±42 |
33±13 |
0.0420 |
1.0000 |
138±48 |
110±61 |
0.7244 |
1.0000 |
|
HPA-RT - stress CORT [μg/l] |
118±13 |
165±15 |
0.0499 |
1.0000 |
207±23 |
260±20 |
0.1018 |
1.0000 |
| EPF - total grooming time [s] |
0.84±0.84 |
4.79±1.77 |
0.0765 |
1.0000 |
1±1 |
1.25±1.25 |
0.8789 |
1.0000 |
| FST - total swimming time [s] |
111±25 |
168±20 |
0.0994 |
1.0000 |
184±27 |
187±38 |
0.9448 |
1.0000 |
| FST - total floating time [s] |
165±24 |
118±21 |
0.1548 |
1.0000 |
128±28 |
119±34 |
0.8423 |
1.0000 |
| OF - total time in the inner zone [s] |
7±2 |
3±2 |
0.2047 |
1.0000 |
6±4 |
11±4 |
0.4170 |
1.0000 |
| EPF - frequency of grooming |
0.3±0.3 |
0.9±0.4 |
0.2297 |
1.0000 |
0.3±03 |
0.5±0.5 |
0.6674 |
1.0000 |
| FST - latency to 1st floating [s] |
110±7 |
95±10 |
0.2469 |
1.0000 |
96±5 |
121±16 |
0.1768 |
1.0000 |
| HPA-RT - basal CORT [μg/l] |
6.8±2.5 |
4.3±0.8 |
0.3724 |
1.0000 |
19±13 |
11±7 |
0.6019 |
1.0000 |
| OF - entries to the inner zone |
5.5±2.5 |
3.1±1.8 |
0.4510 |
1.0000 |
6.8±2.8 |
8.5±3.5 |
0.6991 |
1.0000 |
| EPM - all arm entries |
23±2 |
21±3 |
0.4732 |
1.0000 |
24±2 |
21±3 |
0.3112 |
1.0000 |
| FST - total struggling time [s] |
87±9 |
80±9 |
0.5799 |
1.0000 |
52±7 |
58±8 |
0.6015 |
1.0000 |
| PHYS - body weight [g] |
29±1 |
29±1 |
0.6776 |
1.0000 |
22±1 |
24±1 |
0.1141 |
1.0000 |
| EPM - sum of total arm entries | 23±2 | 21±3 | 0.4600 | 1.0000 | 24±2 | 21±3 | 0.5610 | 1.0000 |