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. 2013 Jan 28;8(1):e55284. doi: 10.1371/journal.pone.0055284

Figure 5. EspF-mediated epithelial barrier dysfunction of TC-7 cells requires the N-WASP binding motif.

Figure 5

Loss of epithelial barrier function as measured by transepithelial electrical resistance (TER) of TC-7 cells infected for 6 h with the indicated EPEC strains. The various ΔespF mutants were complemented with ΔespF variants mutated in the mitochondrial targeting sequence (L16E), the SNX9 binding motif (D3), or 1, 2 or 3 of the N-WASP binding motif (A1, A2, A3 respectively). Data represents the mean ± SD for 3 independent experiments; p values given in the text.