Figure 8. Pathway analysis of genes regulated by 100 nM or 20 nM endoxifen treatments in the presence of estrogen and physiologically relevant levels tamoxifen and its metabolites.

The sub-categories of biological pathways determined to be significantly altered and which were unique to the 100 nM endoxifen treatment (A) or the 20 nM endoxifen treatment (B), or which were commonly regulated by both endoxifen concentrations (C), are shown. The specific biological pathways which are comprised within these sub-categories are listed in Table 1.