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. 2013 Jan 28;8(1):e54932. doi: 10.1371/journal.pone.0054932

Figure 2. Upregulation of miR-195 suppresses the proliferation of glioma cells. A.

Figure 2

, MTT assays revealed that upregulation of miR-195 reduced cell growth of LN18 and T98G glioma cell lines, compared to negative control (NC)-transfected cells. B, Upregulation of miR-195 reduced glioma cell tumorigenicity as determined by anchorage-independent growth assay. Representative micrographs (left) and quantification of colonies that were larger than 0.1 mm (right) were scored. C, Representative micrographs (left) and quantification of BrdU incorporating-cells after transfection with negative control (NC) or miR-195. D, Flow cytometric analysis of indicated glioma cells after transfection with Negative control (NC) or miR-195. Each bar represents the mean of three independent experiments. * P<0.05.